Pendotech DAQ

Pendotech Data Acquisition System for Real-Time Monitoring

The Mettler-Toledo Pendotech DAQ (Data Acquisition System) centralizes real-time bioprocess monitoring and sensor data management of pressure, flow, pH, and conductivity, process data across up to 14 devices, helping biopharmaceutical manufacturers improve process visibility, reduce data silos, and accelerate troubleshooting during downstream bioprocessing and GMP manufacturing.

The system enables operators to monitor, trend, calculate, and log process data in real time for improved process control, troubleshooting, batch consistency, and operational efficiency.

What Is the Pendotech DAQ System?

The Mettler-Toledo Pendotech DAQ is a centralized bioprocess monitoring platform that collects and displays data from multiple in-line sensors and process devices during biopharmaceutical manufacturing.
The DAQ software provides:

Real-time process trending
Centralized sensor visibility
Automated data collection
Electronic process notes
Excel-compatible data export
Calculated process values for filtration applications

By consolidating process data into a single monitoring platform, the DAQ helps operators detect deviations faster and improve decision-making during downstream processing.

Why Centralized Bioprocess Data Matter

When process data is isolated across multiple screens or systems:

Early process deviations may be missed
Troubleshooting becomes slower
Process visibility is reduced
Manual data collection increases operator burden
Batch consistency becomes harder to maintain

The Mettler-Toledo Pendotech DAQ system helps eliminate data silos by creating a centralized view of critical process parameters in real time.

Key Benefits of the Pendotech DAQ System

Real-Time Process Visibility
Monitor pressure, flow, pH, conductivity, Temperature and filtration performance simultaneously through one centralized bioprocess monitoring interface.

Faster Process Deviation Detection
Identify pressure fluctuations, flow interruptions, pH shifts, conductivity changes, or filtration instability earlier to reduce process risk and improve response time.

Simplified Data Collection and Batch Documentation
Automatically collect and store process data in Excel-compatible formats to support batch review, process analysis, electronic recordkeeping, and GMP documentation workflows.

Improved Filtration Monitoring
The DAQ system automatically calculates critical filtration parameters including:

DeltaP
Transmembrane Pressure (TMP)

These real-time calculations help operators optimize membrane performance, identify fouling conditions earlier, and improve filtration consistency. during TFF and UF/DF operations.

Enhanced Process Traceability
Electronic operator notes are automatically logged alongside process data to improve traceability, troubleshooting documentation, and operational review of workflows.

Supported Sensor Inputs and Device Integration

The Pendotech DAQ system supports up to 14 device inputs, including:

4 pressure sensors
2 scales
2 flow meters
1 pH probe
1 conductivity electrode
1 air-in-tube detector
3 configurable analog inputs

Configurable analog inputs may support:

UV sensors
Temperature sensors
Turbidity sensors
Additional analog monitoring devices

This flexible architecture allows manufacturers to build connected monitoring systems tailored to specific bioprocess applications.

Common Applications for Pendotech DAQ

The Pendotech DAQ system is commonly used in:

Downstream bioprocessing
Tangential Flow Filtration (TFF)
Ultrafiltration/Diafiltration (UF/DF)
Chromatography
Buffer preparation
Process development
Single-use bioprocessing systems

How the DAQ Supports Filtration Applications

Filtration performance depends on maintaining stable process conditions across multiple parameters simultaneously.

The DAQ system helps operators monitor:

Pressure trends
Flow consistency
TMP changes
Conductivity shifts
Filtration performance

Real-time monitoring supports:

Faster troubleshooting
Earlier fouling detection
Improved membrane protection
Better filtration consistency
Reduced process downtime

The Pendotech DAQ system helps unify critical process monitoring into one centralized platform, improving operational awareness, and helping teams respond faster to changing process conditions.

Supported Sensor Inputs and Device Connectivity
The Pendotech DAQ system supports a wide range of in-line bioprocess sensors and monitoring devices used in downstream purification, filtration, and process development applications.

Pressure Monitoring

Supports up to 4 pressure inputs using Pendotech Pressure Sensors Compatible with reusable pressure sensors for extended operational use
Enables real-time pressure trending and filtration monitoring during TFF, UF/DF, and chromatography operations

Flow Monitoring

Supports up to 2 flow meters with pulse or frequency signal outputs
Includes standard calibration entry
Helps improve flow consistency monitoring and process control during fluid transfer and filtration workflows

pH and Conductivity Monitoring

Supports traditional electrochemical pH probes
Compatible with conductivity electrodes for real-time buffer and process monitoring
Enables continuous monitoring of critical downstream process parameters

Air Detection and Alarm Monitoring

Integrated air detector supports air-in-line or liquid detection applications
Can be configured as an automated process alarm for improved operational protection and process awareness

Scale Integration

Supports up to 2 scales through RS232 serial communication
Enables real-time weight monitoring during buffer preparation, filtration, and fluid management operations

Configurable Analog Inputs
The DAQ system includes:

2 configurable 4–20mA analog inputs
1 configurable 0–10V analog input

Analog channels may be configured for:

UV flow cell transmitters
Temperature sensors
Turbidity sensors
Additional analog process monitoring devices

Users can configure:

Measurement ranges
Units of measure
Precision and scaling parameters

This flexible architecture allows manufacturers to customize the DAQ platform for specific bioprocess monitoring and PAT (Process Analytical Technology) applications.

Advanced DAQ Monitoring and Alarm Features

Centralized PC Software Interface
The Pendotech DAQ software provides a graphical user interface (GUI) for centralized real-time process monitoring, sensor trending, and data visualization across multiple devices and process parameters.

Critical Alarm Management
Supports configurable alarms for:

Pressure conditions
pH deviations
Conductivity changes
Analog input thresholds

These alarms help operators identify process deviations earlier and improve response time during manufacturing operations.

Pre-Alarm Notifications and Email Alerts
The system supports pre-alarm warning conditions with optional email notifications to improve operational awareness and reduce the risk of process interruptions.

Relay Alarm Output
Integrated dry-contact relay outputs may be used to:

Trigger external alarms
Shut down pumps automatically
Support automated process protection workflows

Filtration Monitoring and Process Calculations
The Pendotech DAQ system supports optional real-time filtration calculations including:

DeltaP
Transmembrane Pressure (TMP)

These calculations help operators:

Monitor membrane performance
Detect fouling earlier
Optimize TFF and UF/DF operations
Improve filtration consistency
Reduce process downtime

Real-Time Trending and Data Logging

Multi-Parameter Trending
Trend and monitor up to 8 process parameters simultaneously for improved process visibility and operational analysis.

Automated Data Logging
All process data is automatically logged to CSV files compatible with Microsoft Excel for:

Batch documentation
Process analysis
Electronic recordkeeping
GMP reporting workflows

Industrial Design and Compliance

Manufactured in a stainless-steel enclosure for bioprocess manufacturing environments
CE Mark certified for compliance with applicable European standards

System View

Trends View

Maintenance View

Pendotech Single-Use Pressure Sensors
Pendotech single-use pressure sensors are designed for in-line pressure monitoring in bioprocessing systems, including Tangential Flow Filtration (TFF), Ultrafiltration/Diafiltration (UF/DF), chromatography, and buffer preparation.

Enable real-time pressure monitoring in single-use and hybrid bioprocess systems
Support improved process visibility and early detection of pressure deviations
Help reduce contamination risk by eliminating cleaning requirements associated with reusable probes
Integrate directly with the Pendotech DAQ System for centralized data acquisition and trending

Air Detector (Air-in-Line Monitoring)
The Pendotech Air Detector provides real-time detection of air or liquid presence in bioprocess flow paths and can also be configured as a process alarm input.

Detects air-in-line conditions to protect pumps, membranes, and downstream process equipment
Supports automated alarm signaling for improved process safety and response time
Helps reduce risk of process interruptions during filtration and fluid transfer operations
Integrates with DAQ alarm and relay systems for automated process protection workflows

pH Probe (Electrochemical Monitoring)
The DAQ system supports traditional electrochemical pH probes used for real-time monitoring of bioprocess pH conditions.

Enables continuous in-line pH monitoring during downstream purification and buffer operations
Supports early detection of pH deviations affecting product stability and process performance
Helps maintain tighter control of critical process parameters in GMP manufacturing environments
Fully integrated with DAQ trending and alarm functionality for real-time process visibility

Conductivity Sensor
The conductivity sensor provides real-time measurement of ionic strength and buffer composition in bioprocess streams.

Supports buffer preparation, chromatography, and downstream purification workflows
Enables monitoring of buffer transitions and conductivity shifts in real time
Helps improve process consistency and product quality control
Integrates with DAQ system for centralized data logging, trending, and analysis

Temperature Sensor
The temperature sensor measures temperature accurately and cost effectively during downstream processes.

Eliminates the cross-contamination for single use application
Designed for in-line use and perfect for filtration and chromatography and process monitoring
Connects with DAQ systems to enable centralized data logging, trend monitoring, and comprehensive analysis.

Data Sheets

PDKT-PCS-DAQ: Pendotech Sensor Data Acquisition System with alarm functions for 14 sensors/devices & PC Software
COND1-TFF Conductivity Probe K=1 with 100ohm Pt RTD for temperature measurement, stainless steel
COND2-TFF Conductivity Probe K=1 with 100ohm Pt RTD for temperature measurement, epoxy
COND3-TFF Conductivity Glass flow cell K=1 for 1/4inch ID tubing w/100ohm Pt RTD for temperature measurement
COND4-TFF Conductivity Probe K=1 with 100ohm Pt RTD for temperature measurement, stainless steel with sanitary flange AD-XX: Ultrasonic air in-line detector (tubing size TBD)

* Please contact your local Pendotech representative for a quote.