In bioreactors, gases are introduced to the sterile
vessel to both the liquid phase of the media and the
gas phase in the head space to both supply the cells
with the required oxygen and to control process
conditions. The exhausted gas exits via a vent filter
from the head space and it is important to use a filter
of adequate size and construction to prevent it from
clogging or becoming occluded with water.

Also, pressure is used as a means of influencing mass
transfer and mitigating contamination. However, an
over pressure situation in a glass or single use
bioreactor can occur at rather low pressures and a
clogged vent filter can cause a vessel to rupture,
particularly on a single use bioreactor bag, spilling
the contents of the reactor and exposing the
operators to unprocessed bulk creating a potentially
hazardous situation.

PendoTECH Single Use Pressure Sensors are an ideal
pressure monitoring solution in this application in the
range of 2 psi and less. They are:

• Compatible with gamma irradiation up to 50 KGy so they can be placed on the bioreactor before it is gamma sterilized. The sensors with the luer fitting are available sterile for aseptic connection after a glass has been autoclaved
• Accuracy within +/- 2% of reading from 0-6 psi (i.e., at 1 psi +/- 0.02 psi)
  SEE PERFORMANCE GRAPH BELOW
• Raw signal from sensor chip compensated for temperature changes from 15-40°C
• Each sensor is tested for accuracy and leaks before being released from manufacturing
• No calibration is required- the sensors come ready to use
• The sensors come in a wide variaty of sizes
• They connect to the PressureMAT, which in addition to reading the sensors has
  4-20 mA signal outputs, an RS-232 output, and alarm relay outputs; and alarm
  relay outputs that can be connected to automated tubing pinch valves for
  pressure relief and control
• Our PendoKIT Custom Control Systems can be configured to monitor 12 or more bioreactors
  
  (CLICK TO DOWNLOAD APPLICATION NOTE)

Six Random Sensors Tested at Low Pressures
Sensor Reading versus Gauge Pressure

10 minute warm-up of sensor is recommended for best accuracy
* Sensors: PendoTECH PREPS-N-000 Single Use Pressure Sensors
* Calibrated Pressure Gauge: NIST Traceable with accuracy of +/- 0.03 psi

Please contact us at request@pendotech.com for more information.

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